I use it on an iPad in landscape mode more or less exclusively, and I seems to work the same to me. That said, I don’t use advanced gestures (or any gestures, actually), so if those changed I wouldn’t notice. But the actual display on my iPad in landscape, navigation, etc., works well.
Wow, a Lain meme was not something I was expecting.
I should watch that show again sometime, I still have the DVDs somewhere I think.